In this paper, we propose a methodology that synthesize and optimize the power network for design with multiple power domains. An architecture is presented to represent the power network with presence of sleep transistors. The power network is numerically modeled to RC network using Modified Nodal Analysis and solved using Conjugate Gradient Method. Regarding to IR drop effect mitigation, an optimization technique is proposed based on Simulated Annealing that minimize total power stripe area while satisfying a given IR drop constraint. The proposed methodology is integrated to commercial design tool and experimented on real design case for evaluation. To ensure practical aspect of our approach, evaluation is performed on latest digital design commercial tool. Design data and parameters are extracted using Open Access. The result of our algorithm is fed back to latest commercial tool for final IR and EM analysis. Our algorithm is tested on both industrial testcase and academic MCNC benchmark. Comparing to conventional P/G network, using our power network synthesis can achieve 31% - 35% reduction in total P/G area while satisfying maximum 10% IR-drop constraint.